|
KMID : 0895820070170030065
|
|
Journal of Oriental Rehabilitation Medicine
2007 Volume.17 No. 3 p.65 ~ p.89
|
|
|
Association Study between UCP-1 Polymorphisms and Korean Obese Female Subjects
|
|
Shin Seung-Uoo
Kim Sung-Su
|
|
|
Abstract
|
|
|
Objectives :This study was conducted to investigate the effects of UCP-1(Uncoupling protein-1) polymorphism on obesity phenotypes. For this, we analyzed association between SNPs(single nucleotide polymorphisms) of UCP-1 -3954A>G, -1766A>G, +940A>G, +6537A>T, and their haplotypes and obesity phenotypes.
Methods :A total of 426 Korean female subjects were recruited from an obesity clinic. All subjects were obesity on BMI(Body mass index) (?25 ㎏/㎡). For genotyping of SNPs, genomic DNA(Deoxyribonucleic acid) from each subject was extracted from whole blood and genotyped by TaqMan Method. Haplotypes and their frequencies were inferred using the algorithm, HapAnalyzer program. BMI, body fat mass, percent body fat, abdominal fat mass, waist circumference, lipid profile, and blood pressure were measured and associations between these and SNPs and haplotypes of UCP-1 were analyzed by age-adjusted general linear model.
Results & Conclusions :There was significant, but not close association between -3954A>G, +940G>A, and haplotype 1-3 of UCP-1 with increased body fat of Korean female subjects. It was found that body fat mass and other obesity phenotype were significantly increased in G allele carriers of -1766A>G polymorphism, while decreased in T allele carriers of +6537A>T polymorphism and haplotype4[GAAT] carriers.
|
|
|
KEYWORD
|
|
|
UCP-1, Polymorphism, Obesity, Korean female
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|